Wednesday, December 31, 2014

Treating Haemophilia With Less Frequent Injections

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Extending the life of clotting factors may improve quality of life for people with haemophilia


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For the parents of a child born with haemophilia, the diagnosis comes with both good and bad news. The good news is that the child, at least if he (or rarely, she) is born in the developed world, can expect a near-normal lifespan, up from a mere 20 years in 1970. The bad is that the parents must teach themselves to find their child's veins, insert a needle and infuse him with a clotting factor to replace what he lacks. Parents must infuse a toddler as often as every other day, and children with haemophilia will have to continue that treatment for the rest of their lives.


But treatment is getting easier. Down the road, gene therapy and other approaches look likely to bring longer-term treatments for patients with the rare bleeding disorder. For now, improvement in treatment lies in the emergence of new, longer-lasting replacements for the blood-clotting factors missing from the blood of people with the condition. These therapies could stretch the time between infusions to days or even weeks. The first two such treatments were approved by the US Food and Drug Administration (FDA) earlier this year, and more are in the pipeline, with some expected to be approved in 2015. As these therapies emerge, dealing with haemophilia will become less troublesome (see below). This could increase compliance with treatment, reduce complications — and perhaps even allow some people to live almost as if they were free of the disease.



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Wonderful Things: Ferns Eject Their Spores with Medieval-Style Catapults

Wonderful Things series. You can


One of the more under-appreciated and ingenious machines evolved by plants is the cavitation catapult of . If that sounds exciting and mysterious, that’s because it is.


This is a leptosporangium, where the fern makes its reproductive cells called spores:


ONF Fig 02 – Sporangium of Polypodium vulgare” by – Our Native Ferns and their Allies Edition 6, 1900. Licensed under Public Domain via .


You’ll notice this one has been broken open and some of the spores formed inside have fallen out. Note also the little striated ring around the upper right, called the “annulus”. It gives the spore capsules the appearance of wearing a .


The bottom of this structure is attached to the underside of a fern frond, and it is usually found in a cluster of dozens just like it. Here’s the way those clusters look on the underside of one fern:


Fern spores P1180804“. Licensed under via .


If you are a stationary being such as a plant or a fungus, it’s in your best interest to devise a method of evicting your offspring in the most expedient and efficient way possible. For ferns with leptosporangia, that means launching them in the manner of a boulder addressed to the nearest crusader castle. Just have a look:



The narrator of this video, a co-author of describing the same findings, mentions that the catapult is launched by a phenomenon called that deserves a little more explanation. When bubbles of gas form spontaneously due to pressure changes in a liquid, that is cavitation. If you’ve watched a lot of submarine movies like me, you know that cavitation is a bad thing because a cavitating propeller makes noise that can give away your position to the Russkies. That’s the swift movement of the propeller blades produces very low water pressure along their edges, creating cavitation bubbles in poorly-designed propellers or propellers driven badly or too quickly. These bubbles collapse once the low-pressure zone passes and they experience normal ocean pressure. The stream of collapses produces noisy shock waves that can be picked up by passive sonar.


In plants, the water pressure usually reaches the low levels that can cause cavitation when plants are thirsty but there’s nothing to drink. In wilting or drought-stressed plants that can’t draw more water from the soil, this can cause big problems. As the water pressure reaches critically low levels inside the plant’s water-conducting vessel cells, they cavitate, forming bubbles in the cells that impede further flow of fluids. The cavitation inside trees .


In the ridged compartments of a leptosporangium’s annulus, evaporation through the thin transparent walls between the rings also produces the low pressure environment conducive to cavitation. But because a fern leptosporangium is a single-use device, cavitation here is not only not destructive, it is desirable and essential. When the bubbles burst into being, the annulus suddenly relaxes like a bow string loosed by an archer, providing the burst of acceleration necessary to carry spores into adjacent zip codes.


But the spores would just get slammed into the bottom of the sporangium by the annulus without some way to halt its motion mid-swing. The narrator points out that every respectable medieval catapult contained a crossbar for stopping the arm and launching the payload. You have no doubt noted that the fern leptosporangium lacks such a device. So what halts the rebound of the annulus?


The answer is viscosity. The paper explains the effect using a lesser-known relation called ““. The walls of the annulus are especially thick and spongy. Water moving through the walls as the annulus springs back is subject to a lot of . This drag is created by the difference in the speed of water moving next to walls (slow) and that moving farther away from them (faster), which induces internal friction in the water molecules moving at different speeds.


Because there are so many tiny pores (and hence more wall surface area) in the cellulose of the annulus, the viscous drag is great, dissipating the energy of the rebound and halting the catapult arm. The spores, encountering no similar resistance to their motion, continue off into the wild blue yonder, with any luck landing on a patch of fertile, fern-free ground.


I’ll leave you with a music video featuring firing fern sporangia so you can observe this fascinating phenomenon some more. To me, it looks a bit like the fern is engaged in a spore-snowball fight with itself. Note that stray spores that fall from the sporeballs as they go sailing past get stuck to the plant and cover of the sporangia. It’s good, clean, messy botanical fun.



ReferenceNoblin X., J. Westbrook, C. Llorens, M. Argentina & J. Dumais (2012). The Fern Sporangium: A Unique Catapult, Science, 335


Data Point to "Unbelievably" Steep Climb before AirAsia Crash

AirAsia Flight QZ8501's steep climb before it crashed possibly pushed it beyond the Airbus A320's limits, said a source familiar with the probe's initial findings



December 31, 2014


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By Siva Govindasamy


SURABAYA, Indonesia, Dec 31 (Reuters) - Radar data being examined by investigators appeared to show that AirAsia Flight QZ8501 made an "unbelievably" steep climb before it crashed, possibly pushing it beyond the Airbus A320's limits, said a source familiar with the probe's initial findings.


The data was transmitted before the aircraft disappeared from the screens of air traffic controllers in Jakarta on Sunday, added the source, who declined to be identified.


"So far, the numbers taken by the radar are unbelievably high. This rate of climb is very high, too high. It appears to be beyond the performance envelope of the aircraft," he said.


The source added that the data on which those assumptions had been made were incomplete. Colleagues and friends of the Indonesian captain on board have described him as an experienced and professional pilot.


The preliminary findings sharpen the focus on the role bad weather and the crew's reaction to storms and clouds in the area had to play in the plane's crash into the Java Sea which killed all 162 people on board.


Finding the six-year-old plane's cockpit voice recorder (CVR) and flight data recorder (FDR), more commonly known as black boxes, was vital to complement the radar data already available.


"With the CVR and FDR, we can establish what went on in the cockpit and what was going on with the aircraft. We can conclude if the radar information is accurate," added the source.


CLIMBING TOO SLOWLY?


At 6.12 a.m. on Sunday, 36 minutes after taking off from Surabaya's Juanda Airport on a flight to Singapore, the pilot asked for permission to climb to 38,000ft from 32,000ft and deviate to the left to avoid bad weather.


Two minutes later, Jakarta responded by asking QZ8501 to go left seven miles and climb to 34,000ft. There was no response from the cockpit. The aircraft was still detected by the ATC's radar before disappearing at 6.18 a.m.


An image that was reportedly leaked from AirNav Indonesia, which manages the country's air space, and shared on several websites, appeared to show QZ8501 at an altitude of 36,300ft and climbing at a speed of 353 knots.


The source declined to confirm if that image was accurate. Officials from AirNav Indonesia declined to comment.


Two veteran pilots told Reuters that, if accurate, the image and information released so far pointed to the fact that the aircraft may have climbed suddenly and then lost speed.


This can result in the aircraft stalling in mid-air before plunging to the sea, they said.


One pilot explained that an A320 would cruise at a speed of around Mach 0.78 while at an altitude of 32,000ft. That translates into roughly 516 knots.


"If you encounter turbulence, you go slower at what we call the turbulence penetration speed to get through it. If you climb to avoid turbulence, you slow down to have a better climb rate. That could be around Mach 0.76," he said. "But if you climb suddenly and start to lose speed, you will stall."


The source close to the probe said other aircraft in the area at the time of the crash were flying at higher altitudes. Aircraft tracking website flightradar24.com said that they were at between 34,000 and 39,000 feet.


"We know that there was severe local weather and big clouds. But they (the other planes) were higher and did not appear to encounter any major problems. We want to look into that too," added the source.


Industry sources told Reuters that there could be parallels between this incident and the crash of Air France flight AF447 in 2009.


The investigation into that Airbus A330 showed that the co-pilot lost speed readings due to icing on the airframe.


His panic reaction meant that he kept trying to climb despite repeated stall warnings, and the crew failed to recognize the situation, eventually sending the aircraft plunging into the Atlantic.


Incidents like these show that the margin for error at higher altitudes is smaller than at takeoff or lower down, say industry experts.


They add that the A320's systems usually prevent pilots from doing anything outside usual safe flight parameters. But these protections can be disabled in some circumstances, handing control to the pilots and leaving it to manual flying skills.


(Additional reporting by Jane Wardell in SYDNEY and Tim Hepher in PARIS; Editing by Mike Collett-White)


Climate Change Will Alter the Taste of Wine

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Winegrowers are trying to preserve the flavor of your favorite reds and whites as climate change alters the compounds in grapes


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It was a hot day in the vineyard, and I was covered in dust, sweat and sticky juice from the grapes I had been collecting for my research on how grape biochemistry is affected by light and temperature. Suddenly, I saw something that made me stop short. Tucked in one corner of this 6.5-acre plot in Carneros, in California's fabled Sonoma Valley, with row after neat row of Pinot Noir grapes, were a handful of alien vines. I had studied the arcane art of ampelography—the practice of identifying grapevines by the shape of their leaves and clusters, as part of my graduate training in viticulture—so I took an educated guess at what they were: the red varieties Cabernet Franc, Petit Verdot, Syrah and Malbec, plus a white, Sauvignon Blanc.


The next time I saw Ned Hill, an old friend from high school in nearby Napa who now managed some of the finest vineyards in the region, including this one, I asked him about those strange vines. “That's an experiment I'm doing,” he said. “We're already pretty warm around here for growing Pinot. The price is good right now, so I don't want to make any changes. But pretty soon we might do better growing something else, so I'm trying out some war mer-climate varieties.”



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Tuesday, December 30, 2014

Publication Bias May Boost Findings For Bilingual Brain Benefits

Of studies presented at conferences, those that found a cognitive benefit to bilingualism were almost twice as likely to get published in journals as were studies finding no benefit. Karen Hopkin reports. December 30, 2014 | |

Over the past 10 years, many scientific papers have shown that speaking more than one language can convey some cognitive rewards. For example, bilingualism seems to boost the brain’s ability to focus, , and . But a few papers show no such advantages.Now a study finds that research that challenges a bilingual benefit is less likely to be published than studies that find one. This party pooping, or fiesta-foiling, finding is in the journal . [Angela de Bruin, Barbara Treccani and Sergio Della Sala, Researchers compared studies presented at conferences to those actually accepted for publication. Of the 104 meeting abstracts they examined, about half supported a bilingual advantage and half challenged or failed to find one.But when it came to publication, 63 percent of the bilingual boosting studies made it into a scientific journal, as opposed to 36 percent of the studies with null findings.The data do not address whether the bias toward affirmative results comes from the journal editors and reviewers or from the scientists themselves. And they don’t suggest that bilingualism offers no advantages. Regardless of brain function, there exist undeniable social benefits to having two tongues versus just one.—Karen Hopkin


Lightning May Sink Mountain Summits


Magnetic anomolies in rocks indicate that lightning may be a major player in weathering mountains. Julia Rosen reports. December 30, 2014 | |


Rocks are pretty tough, but eventually, even the . Geologists usually give the credit to water and ice. But when it comes to smashing summits, a major player may be . Scientists have found evidence for lightning’s role in mangling mountains in the magnetic signatures of rocks, which go haywire when blasted by bolts.“I mean, these magnetic anomalies are huge.” Susan Webb of the University of Witwatersrand in South Africa. “And so, we don’t expect to see that, not with ice fracturing rocks. We would see that only with lightning fracturing rocks. And the fact that there’s so many tells you that’s a really important mechanism for weathering rocks.”Webb presented her results on December 18th at the annual meeting of the American Geophysical Union in San Francisco. [Susan Webb, Jasper Knight and Stefan Grab, ]As a test case, in the southern African country of Lesotho, a place with lots of mountains and lots of lightning. But Webb says she’s only scratched the surface. “And I think as we look more and more for this, and it’s very easy to look for if we do magnetic surveys in these areas, we will see it. Then we’ll be able to tell if this is a much more widespread phenomenon.”—Julia Rosen


Bodies and Debris From Missing AirAsia Flight Pulled From Sea Off Indonesia

By Gayatri Suroyo and Adriana Nina Kusuma


SURABAYA, Indonesia/JAKARTA, Dec 30 (Reuters) - Indonesian rescuers searching for an AirAsia plane carrying 162 people pulled bodies and wreckage from the sea off the coast of Borneo on Tuesday, prompting relatives of those on board watching TV footage to break down in tears.


Indonesia AirAsia's Flight QZ8501, an Airbus A320-200, lost contact with air traffic control early on Sunday during bad weather on a flight from the Indonesian city of Surabaya to Singapore.


The navy said 40 bodies had been recovered. The plane has yet to be found.


"My heart is filled with sadness for all the families involved in QZ8501," airline boss Tony Fernandes tweeted. "On behalf of AirAsia, my condolences to all. Words cannot express how sorry I am."


The airline said in a statement that it was inviting family members to Surabaya, "where a dedicated team of care providers will be assigned to each family to ensure that all of their needs are met".


Pictures of floating bodies were broadcast on television and relatives of the missing already gathered at a crisis centre in Surabaya wept with heads in their hands. Several people collapsed in grief and were helped away.


Yohannes and his wife were at the centre awaiting news of her brother, Herumanto Tanus, and two of his children who were on board the doomed flight.


The Tanus family had been on their way to visit Herumanto's son, who studies in Singapore and who travelled to Surabaya on Monday after the plane went missing.


"He cries every time he watches the news," Yohannes said.


The mayor of Surabaya, Tri Rismaharini, comforted relatives and urged them to be strong.


"They are not ours, they belong to God," she said.


Searching through the night


"The challenge is waves up to three metres high," Fransiskus Bambang Soelistyo, head of the Search and Rescue Agency, told reporters, adding that the search operation would go on all night. He declined to answer questions on whether any survivors had been found.


About 30 ships and 21 aircraft from Indonesia, Australia, Malaysia, Singapore, South Korea and the United States have been involved in the search.


The plane, which did not issue a distress signal, disappeared after its pilot failed to get permission to fly higher to avoid bad weather because of heavy air traffic, officials said.


It was travelling at 32,000 feet (9,753 metres) and had asked to fly at 38,000 feet, officials said earlier.


Pilots and aviation experts said thunderstorms, and requests to gain altitude to avoid them, were not unusual in that area.


The Indonesian pilot was experienced and the plane last underwent maintenance in mid-November, the airline said.


Online discussion among pilots has centred on unconfirmed secondary radar data from Malaysia that suggested the aircraft was climbing at a speed of 353 knots, about 100 knots too slow, and that it might have stalled.


Investigators are focusing initially on whether the crew took too long to request permission to climb, or could have ascended on their own initiative earlier, said a source close to the probe, adding that poor weather could have played a part as well.


He cautioned that the investigation was at an early stage and the black box flight recorders had yet to be recovered.


Clues when things go wrong


Such systems are mainly used on long-haul flights and can provide clues to airlines and investigators when things go wrong.


Three airline disasters involving Malaysian-affiliated carriers in less than a year have dented confidence in the country's aviation industry and spooked travellers across the region.


Malaysian Airlines Flight MH370 went missing on March 8 on a trip from Kuala Lumpur to Beijing with 239 passengers and crew on board and has not been found. On July 17, the same airline's Flight MH17 was shot down over Ukraine, killing all 298 people on board.


Bizarrely, an AirAsia plane from Manila skidded off and overshot the runway on landing at Kalibo in the central Philippines on Tuesday. No one was hurt.


On board Flight QZ8501 were 155 Indonesians, three South Koreans, and one person each from Singapore, Malaysia and Britain. The co-pilot was French.


U.S. law enforcement and security officials said passenger and crew lists were being examined but nothing significant had turned up and the incident was regarded as an unexplained accident.


Indonesia AirAsia is 49 percent owned by Malaysia-based budget carrier AirAsia.


The AirAsia group, including affiliates in Thailand, the Philippines and India, had not suffered a crash since its Malaysian budget operations began in 2002.


(Additional reporting by Fergus Jensen, Wilda Asmarini, Charlotte Greenfield, Fransiska Nangoy, Cindy Silviana, Kanupriya Kapoor, Michael Taylor, Nilufar Rizki and Siva Govindasamy in JAKARTA/SURABAYA, Al-Zaquan Amer Hamzah and Praveen Menon in KUALA LUMPUR, Saeed Azhar, Rujun Shen and Anshuman Daga in SINGAPORE, Jane Wardell in SYDNEY, Tim Hepher in PARIS and Mark Hosenball, David Brunnstrom and Lesley Wroughton in WASHINGTON; Writing by Dean Yates and Robert Birsel; Editing by Nick Macfie and Mike Collett-White)


Temps Plunge U.S. into Deep Freeze, with Snow for Las Vegas

Colder-than-average temperatures locked large swaths of the U.S. into a deep freeze Tuesday



December 30, 2014


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By Mark Guarino


CHICAGO (Reuters) - As colder-than-average temperatures locked large swaths of the United States into a deep freeze Tuesday, snow was likely in an unlikely place - Las Vegas.


The National Weather Service (NWS) said cold air pressure from the northern High Plains would move south starting Tuesday, producing light snow and sleet over parts of western Texas that will expand into parts of the Southwest Tuesday night into Wednesday. Light rain is expected to develop over parts of Southern California and the desert Southwest on Wednesday.


The NWS said Las Vegas temperatures fell below freezing Monday and would continue through Thursday at an average low of 30 degrees. Up to 3 inches of snow was expected by Tuesday night.


"Many tourists who come to Las Vegas may be unprepared for the true winter-like conditions this storm could bring with it," the NWS said in a statement. "Travel conditions could be difficult, if not impossible, on area roads."


Las Vegas does not have snowplows but the Nevada Department of Transportation said it has six snowplows at the ready if the snow poses a significant threat to roads. The Las Vegas Convention and Visitors Authority is expecting about 340,000 visitors for New Year’s Eve celebrations, it said.


Cold arctic air will spread throughout the Upper Midwest, where temperatures will fall 20 to 30 degrees below normal Tuesday and Wednesday, producing light snow in some parts. The falling temperatures will be accompanied by dangerous wind chill values between 20 to 30 degrees below zero, which will make the cold feel unseasonably brittle.


In Milwaukee, a low temperature of about 5 degrees was expected Tuesday with the high on Wednesday predicted to reach only 18 degrees, the NWS reports.


Farther east, light snow is expected over the Central Appalachians Tuesday with light rain to develop over the Mid-Atlantic down to parts of Florida late Tuesday through Wednesday night.


(Reporting by Mark Guarino; Editing by Bill Trott)


What Rare Disorder Is Hiding in Your DNA?

Last spring Laura Murphy, then 28 years old, went to a doctor to find out if a harmless flap of skin she had always had on the back of her neck was caused by a genetic mutation. Once upon a time, maybe five years ago, physicians would have focused on just that one question. But today doctors tend to run tests that pick up mutations underlying a range of hereditary conditions. Murphy learned not only that a genetic defect was indeed responsible for the flap but also that she had another inherited genetic mutation.


This one predisposed her to long QT syndrome, a condition that dramatically increases the risk of sudden cardiac death. In people with the syndrome, anything that startles them—say, a scary movie or an alarm clock waking them from a deep slumber—might kill by causing the heart to beat completely erratically.


Doctors call this second, unexpected result an “incidental finding” because it emerged during a test primarily meant to look for something else. The finding was not accidental, because the laboratory was scouring certain genes for abnormalities, but it was unexpected.


Murphy, whose name was changed for this story, will most likely have plenty of company very soon. The growing use of comprehensive genetic tests in clinics and hospitals practically guarantees an increasing number of incidental discoveries in coming years. Meanwhile the technical ability to find these mutations has rapidly outpaced scientists’ understanding of how doctors and patients should respond to the surprise results.


Unknown Unknowns


What makes incidental findings from genetic tests different, however, is their even greater level of uncertainty. Geneticists still do not know enough about how most mutations in the human genome affect the body to reliably recommend any treatments or other actions based simply on their existence. Furthermore, even if the potential effects are known, the mutation may require some input from the environment before it will cause its bad effects. Thus, the presence of the gene does not necessarily mean that it will do damage. Genetics is not destiny. In Murphy's case, her mutation means that she has a roughly 50 to 80 percent chance of developing long QT syndrome, and the presence of the mutation alone is not a sure indicator she will be afflicted, says her physician, Jim Evans, a genetics and medicine professor at the University of North Carolina School of Medicine. To be safe, he has advised her to meet with a cardiac specialist to talk about next steps, including possibly starting beta-blocker drugs to regularize her heart rate.


The incidence of hard-to-interpret results is expected to rise because the cost of surveying large swaths of the genome has dropped so low—to around $1,000. It is typically less expensive to get preselected information about the 20,000 or so genes that make up a person's exome—the section of the genome that provides instructions for making proteins—than to perform a more precision-oriented test that targets a single gene. As a consequence, scientists and policy makers are now scrambling to set up guidelines for how much information from such testing to share with patients and for how best to help them deal with the inevitable incidental findings.


Before making any definitive recommendations, however, they need to know how often genetic results produce such findings. To that end, Evans is heading up the NCGENES clinical trial, part of a larger effort by three organizations, including the University of North Carolina School of Medicine. Of the roughly 300 patients who have received genetic information since Evans started ordering whole exome tests a couple of years ago, he says, six of them (or 2 percent) had incidental findings that required further testing or decisions about treatment.


Separately, Christine Eng, medical director of the DNA Diagnostic Laboratory at the Baylor College of Medicine, says her team has conducted more than 2,000 whole exome tests since October 2011 with about 95 incidental findings. “That's an incidence of about 5 percent,” she notes. Most of the findings did not require immediate action. Usually they prompt more frequent screening tests, often for breast cancer or colorectal cancer.


Balancing Act


Such advice is particularly important given how often children undergo genetic tests nowadays. “About 80 percent of our cases are pediatric-aged, so the incidental findings are being found in the children, and many of the conditions are adult-onset conditions,” Eng says. Families given such information about their children then may have to wait decades before they can do anything about it or decide when, if ever, to start considering treatment for a disorder that may not ever develop.


Yet a year after issuing its guidance, the ACMG produced an addendum: patients should have the opportunity to opt out of having information about even that short list of analyzed genes. “When families are given a choice, a very large percentage of them want this information, but there are some individuals who feel they do not want this information, so I think this option is a good one,” says Eng, who was not on that decision-making board.


For her part, Murphy is still grappling with how to respond to her incidental finding. She is not yet 30, and she finds it hard to imagine being young and carefree and on beta blockers. “Generally, I'm a very healthy person. I was doing just fine until now, so why does it matter that I found this out?” she asks. “I've been giving it a lot of thought, and if I hadn't gotten [the test] done, I might never have known about this. Now I'm wondering if I really want a lifestyle change. It's a lot to think about.” Yet the hope is that Murphy's experience, and those of other patients, will help geneticists decide which tests to include in future gene scans and better prepare patients and health care workers for dealing with any unwelcome surprises.


The Best Gene Screen


Cancers and Precancerous Conditions



  • Familial adenomatous polyposis—

  • Familial medullary thyroid cancer—

  • Hereditary breast and ovarian cancer—

  • Li-Fraumeni syndrome—

  • Lynch syndrome—

  • Multiple endocrine neoplasia type 1—

  • Multiple endocrine neoplasia type 2—

  • MYH-associated polyposis and related conditions—

  • Peutz-Jeghers syndrome—

  • PTEN hamartoma tumor syndrome—

  • Retinoblastoma—

  • Von Hippel–Lindau syndrome—

  • WT1-related Wilms tumor—


Heart and Vascular Disorders



  • Arrhythmogenic right ventricular cardiomyopathy—

  • Certain other cardiomyopathies—

  • Catecholaminergic polymorphic ventricular tachycardia—

  • Ehlers-Danlos syndrome (vascular type)—

  • Long QT syndromes and Brugada syndrome—

  • Marfan syndrome and related conditions—


Noncancerous growths



  • Hereditary paraganglioma-pheochromocytoma syndrome—

  • Neurofibromatosis type 2—

  • Tuberous sclerosis complex—


Other



  • Familial hypercholesterolemia—

  • Malignant hyperthermia susceptibility—


Cow Dung Itself Breeds Antibiotic Resistance

When antibiotics first became available, farmers used them indiscriminately—dribbling streptomycin into chicken feed to boost growth and doling out low doses to fatten pigs. Now scientists know that the overuse of antibiotics in livestock can foster drug-resistant bacteria that are dangerous to human health. Amid debates over what kinds of restrictions should be put in place, figuring out how antibiotic-resistant bacteria evolve and make their way to humans remains an area of intense interest.


Jo Handelsman is tracing one such pathway that, as she puts it, travels from “barn to table.” Handelsman, a microbiologist who is now associate director for science at the White House Office of Science and Technology Policy, looked into dairy cows, which are often treated with antibiotics and produce manure that farmers use on their crops. In addition to nutrients, that fragrant fertilizer may harbor antibiotic-resistant bacteria—a problem because the microbes can come into contact with plants that are subsequently shipped to supermarkets and sometimes eaten raw.


To tease out how those antibiotic-resistant bacteria come to exist, Handelsman and her colleagues at Yale University added manure from a nearby Connecticut farm to raised beds of soil in 2013. In this case, the manure specifically came from cows that were not treated with antibiotics. The researchers unexpectedly found that soil bacteria carrying antibiotic-resistant genes became more abundant when they were grown with the manure than when they were grown with synthetic nitrogen-based fertilizer—even though the cows were drug-free. The team published its work in October in the .


Previous research has found that manure from pigs treated with antibiotics contains resistant bacteria, including , but the cow-pie results suggest there are more factors promoting resistance besides antibiotic use. Something about manure itself may encourage naturally resistant bacteria to proliferate.


The findings should not, however, give the perception that resistance is everywhere, notes Lance Price, a microbiologist at George Washington University (who was not involved in the study). Widespread resistance is not inevitable, he says. “We can control this. There's very clear evidence that when we turn off the antibiotic spigot, we bring down drug-resistant bacteria.”


Next on the farm-to-table agenda, Handelsman will test whether radishes grown in soil treated with cow manure are capable of taking up resistant genes from bacteria via their vascular system. “They have veins just like us,” she says. “We don't have any evidence yet that they're taking up the bacteria, but it's a really interesting possibility.”


NASA Launches Next-generation Scientific Balloon

NASA has launched its most ambitious scientific balloon ever. On December 28 at 21:16 London time, technicians inflated and released a 532,000-cubic-metre aerostatic balloon from near McMurdo Station in Antarctica. It is the biggest test yet of a 'super-pressure' design that enables a balloon to stay aloft much longer than a conventional scientific balloon.


If all continues smoothly, experts expect the flight to last for 100 days or longer. The current record for the longest NASA scientific ballooning flight is 55 days, using a traditional balloon. The record for a super-pressure balloon is just a day shorter, at 54 days.


More time aloft equals more science. The new super-pressure balloon is carrying a γ-ray telescope to hunt for high-energy photons streaming from the cosmos. Known as the Compton Spectrometer and Imager (COSI), it can detect where in the sky these γ rays are coming from, and thus begin to unravel various astronomical mysteries.


COSI is the first science payload designed from scratch to take advantage of NASA’s super-pressure technology, says team leader Steven Boggs, an astrophysicist at the University of California, Berkeley. Its predecessors used liquid nitrogen to cool themselves, meaning that the nitrogen ran out in less than 10 days. COSI carries a mechanical cooler that contains nothing to run out of.


The imager stares upward and gathers data through the body of the balloon above it, which is transparent at the γ-ray energies it studies. It can scan about 50% of the sky overhead during the course of a day.


One of its main goals is to measure polarization in γ rays streaming from γ-ray bursts, black holes, pulsars and other cosmic phenomena. The longer it flies, the more data it will be able to gather. “The long flight time is key for this study,” says Boggs.


NASA has been pushing to expand its balloon programme as a way to get payloads above most of Earth’s atmosphere without the expense of a satellite launch.


Conventional helium balloons shrink at night, because the pressure of the gas inside them decreases when the temperature cools. The reduced volume makes the balloons lose buoyancy, and therefore altitude. They regain some of that altitude during the heat of the day, but the constant fluctuations up and down make it harder to gather clean data. Actively adjusting for the fluctuations requires releasing gas and dropping of ballast, both of which limit the duration of the flight.


In contrast, have embedded ropes that keep their volume roughly constant, helping them to keep a roughly constant altitude in a passive manner. “It gives you a stable altitude when the Sun goes away,” says Debora Fairbrother, head of NASA’s balloon programme office at the Wallops Flight Facility on Wallops Island, Virginia.


NASA tested its 532,000-cubic-metre super-pressure balloon in Kiruna, Sweden, in 2012, but the new launch is the first to carry major science. It is carrying a payload of 2,300 kilograms to an altitude of about 33.5 kilometres.


Because the flight may last for 100 days or more, the agency had to get permission from countries such as New Zealand in case the balloon drifts into their airspace, Fairbrother says. Conventional balloon flights that last only a few weeks generally make a circuit or two around Antarctica, blown by the circumpolar winds. If COSI goes as long as expected, it could leave the continent and move northward.


From there, it’s a matter of watching and waiting and bringing the balloon and its payload down on a landmass where NASA can recover the telescope. “If we have to terminate over water, it’s lost,” Fairbrother says. (The 54-day record for a super-pressure balloon flight could have gone longer except for the fact that NASA had to bring it down over land because it did not have permission to leave the continent.)


The COSI team has already seen its share of ballooning heartbreak. In 2010, during a conventional balloon launch in Alice Springs, Australia, the instrument that was the COSI predecessor was lost when the balloon wouldn’t release from the deployment mechanism. The December 28 launch was also delayed a year because of the US government shutdown in October 2013, which .




Banking Culture Encourages Dishonesty

Across the globe, many people and institutions suffered large costs from the 2008 financial meltdown. Among the victims is the financial sector itself—whose reputation has been questioned after scandals involving the manipulation of interest rates and fraudulent deals. In trying to make sense of the crisis, some have pointed the fingers to individual bankers and banks, others to institutional pressures. But new research suggests that one important cause may reside elsewhere: in the banking culture itself. A found that the financial sector’s culture encourages dishonesty.


This is an important finding, as it suggests that good conduct starts with having the right culture. Finance CEOs and upper management need to change cultural norms, so that they can model good behavior at all levels of banks and assure that performance incentives don’t inadvertently reward dishonesty. But what, you may be wondering, is unique about banking culture? The fact that there is a lot of focus on money and number crunching.


For the study published in Nature, Alain Cohn and his colleagues divided 128 employees of a large bank into two groups. In the first group, bankers were primed to think about their professional identity, with questions such as “what is your function at this bank?” Bankers in the second group, instead, completed a survey about their wellbeing and everyday life that did not include questions about to their professional life. Next they all tossed a virtual coin 10 times, in private, knowing each time which outcome would earn them $20 for the flip. They then had to report their results online to claim any winnings. The second group of bankers behaved honestly—reporting half heads, half tails—but there was cheating among those whose professional identity had been primed. In their case, in fact, the percentage of winning tosses came in at an incredibly fortunate 58.2 percent. Interestingly, the researchers also conducted the same experiment in other industries but did not find the same skewing when employees were primed to think about their work.


The authors conclude that the prevailing business culture in the banking industry weakens and undermines honesty. Research in moral psychology and behavioral ethics, however, suggests that the dishonesty may be due something more basic: money and number crunching are an important part of the banking industry. When people are focused on money, , they behave in self-interested ways. Even thinking about money leads people to be less helpful and fair in their dealings with others, to be less sensitive to social rejection, and to work harder toward personal goals. In fact, money can make us so focused on our selfish motives that it can even lead to unethical behavior. , for instance, I find that university students were more likely to cheat after seeing 7,000 dollar bills than after seeing 24. Similarly, study participants were more likely to cheat when they were primed to think about money.


The banking industry is not only about money: it also involves a lot of number crunching. And, research suggests, even basic math calculations increase people’s likelihood of engaging in selfish and unethical behavior. finds that number crunching put people in a “calculative mindset” that makes them more likely to focus on a quantitative approach to solving a problem, overlooking a decision’s moral consequences. This narrowly focused “crunch the numbers” approach, they show, has unintended consequences in the way that organizations approach decision-making. After engaging in a calculative task, participants in their experiments were more likely to succumb to the temptations of higher payoffs by acting more selfishly or dishonestly. Thus, the mere act of calculating can activate a calculative mindset that crowds out moral concerns.


Together, this body of work may seem very discouraging. After all, money is ubiquitous in our daily lives, and number crunching is very prominent in our Western culture’s psyche. But money is not the only ubiquitous resource. Another one is time. Benjamin Frank once said that “time is money,” thus suggesting that the two resources are equal. Yet, we treat them differently. Whereas money is a self-serving resource, time is an interpersonally connecting and more personally meaningful resource. For instance, shows that people induced to think about time, rather than money, are more likely to choose to spend time with loved ones over work obligations. Additionally, time is used in more intimate situations than money: people use money in transactions with everyone from close friends to perfect strangers, but they use time almost exclusively for the people and things that really matter to who they are. Thinking about time triggers greater self-reflection than money. Such self-reflection may be a simple exercise, but it is an important one: it reminds us of that we want to be good people.


In my own research, I find that thinking about time encourage people to reflect on who they are, making them more conscious of how they conduct themselves. Given that people desire to see themselves as good people, triggers that encourage them to reflect on who they are affect their behavior. Priming people to think about time, rather than money, lead to less selfish and more ethical behavior. For instance, , half of the study participants completed a series of task while sitting in a cubicle with a mirror on their desk. Participants who had been primed to think about money cheated 39 percent of the time when a mirror was present but 67 percent when it was not. Those who had been primed to think about time cheated 32% of the time in the presence of the mirror and 36 percent in its absence—a percentage that is statistically the same. In this study, the mirror triggered self-reflection. This made a difference for those participants thinking about money: they behaved more honestly. But for those participants thinking about time, it was the time prime who triggered self-reflection and thus the mirror was unnecessary.


The French author and philosopher Albert Camus once said, “Man is the only creature that refuses to be what he really is.” Having the strong desire to be a good person is important, but it may not be enough to assure our actions reflect such desire. By recognizing the pervasive effects money can have, we can be more mindful of our actions, and we can make sure we have opportunities in our busy lives to stop and reflect—to make time to think about time.


@garethideas



Search Expands for Missing AirAsia Uet, U.S. Sends Warship

By Fergus Jensen


JAKARTA, Dec 30 (Reuters) - Countries around Asia on Tuesday stepped up the search for an AirAsia plane carrying 162 people that is presumed to have crashed in shallow waters off the Indonesian coast, with Washington also sending a warship to help find the missing jet.


Soelistyo, head of Indonesia's search and rescue agency, told local television the search area between the islands of Sumatra and Borneo would be expanded. Authorities would also begin scouring nearby islands as well as coastal land on Indonesia's side of Borneo.


So far the focus of the search has been the Java Sea.


There have been no confirmed signs of wreckage from the Airbus A320-200 operated by Indonesia AirAsia, which disappeared in poor weather on Sunday morning during a flight from the Indonesian city of Surabaya to Singapore.


The missing plane, which was carrying mainly Indonesians, could be at the bottom of the sea, Soelistyo said on Monday.


The Java Sea is relatively shallow, making it easier to spot wreckage in the water, say oceanographers, but strong currents and winds in the area mean any debris would be drifting up to 50 km (31 miles) a day east, away from the impact zone.


"The lesson that should be learned from MH370 is that you need to move quickly," said Charitha Pattiaratchi, an oceanographer at the University of Western Australia, referring to the Malaysia Airlines flight that went missing on March 8 during a trip from Kuala Lumpur to Beijing with 239 passengers and crew and which has not been found.


Around 30 ships and 21 aircraft from Indonesia, Australia, Malaysia, Singapore and South Korea would search up to 10,000 square nautical miles on Tuesday, officials said.


Indonesian Air Force spokesman Hadi Tjahjanto said authorities would investigate an oil spill sighted on Monday, although a separate possible slick turned out to be a reef.


Searchers had investigated several areas where possible debris had been sighted in the water but had found nothing connected to the missing plane, Tjahjanto told Reuters.


Authorities would also investigate reports by local fishermen of an explosion on Sunday morning off an island in the area, Tjahjanto added, although dynamite fishing is common in Indonesian waters.


The U.S. military said the USS Sampson, a guided missile destroyer, would be on the scene later on Tuesday.


"We stand ready to assist in any way possible," Pentagon spokesman Mark Wright said.


COULD PLANE HAVE STALLED?


What happened to Flight QZ8501, which had sought permission from Indonesian air traffic control to ascend to avoid clouds, is still a mystery.


Online discussions among pilots have centred on unconfirmed secondary radar data from Malaysia that suggested the aircraft was climbing at a speed of 353 knots, about 100 knots too slow in poor weather, and that it might have stalled.


While searchers had picked up an emergency locator signal off the south of Borneo, no subsequent signal was found, officials said.


The plane, whose engines were made by CFM International, co-owned by General Electric and Safran of France, lacked real-time engine diagnostics or monitoring, a GE spokesman said. Such systems are mainly used on long-haul flights and can provide clues to airlines and investigators when things go wrong.


Officials said the sea in the general search area was only 50 to 100 (150 to 300 feet) metres deep, which would be a help in finding the plane.


"The Java Sea area where they are now searching isn't even an ocean, it's more of an inland sea," Erik van Sebille, a physical oceanographer at the University of New South Wales in Sydney told Reuters.


"It's so shallow that they may just be able to spot the plane," said van Sebille, noting that sunlight travels through water up to about 100 metres.


Oceanographer Pattiaratchi said debris would normally be expected to float on the surface for around 18 days before sinking.


Three airline disasters involving Malaysian-affiliated carriers in less than a year have dented confidence in the country's aviation industry and spooked air travellers across the region.


In the third incident, Malaysia Airlines Flight MH17 was shot down over Ukraine on July 17, killing all 298 people on board.


NO FOUL PLAY SEEN


On board Flight QZ8501 were 155 Indonesians, three South Koreans, and one person each from Singapore, Malaysia and Britain. The co-pilot was French.


U.S. law enforcement and security officials said passenger and crew lists were being closely examined but so far nothing significant had turned up and that the incident was still regarded as an unexplained accident.


The plane, which did not issue a distress signal, disappeared after its pilot failed to get permission to fly higher because of heavy air traffic, officials said.


Pilots and aviation experts said thunderstorms, and requests to gain altitude to avoid them, were not unusual in that area.


The Indonesian pilot was experienced and the plane last underwent maintenance in mid-November, the airline said.


Indonesia AirAsia is 49 percent owned by Malaysia-based budget carrier AirAsia.


The AirAsia group, including affiliates in Thailand, the Philippines and India, had not suffered a crash since its Malaysian budget operations began in 2002.


The plane's disappearance comes at a sensitive time for Jakarta's aviation authorities, as they strive to improve the country's safety reputation to match its status as one of the airline industry's fastest growing markets.


(Additional reporting by Wilda Asmarini, Fransiska Nangoy, Cindy Silviana, Kanupriya Kapoor, Michael Taylor, Nilufar Rizki and Siva Govindasamy in JAKARTA, Al-Zaquan Amer Hamzah and Praveen Menon in KUALA LUMPUR, Saeed Azhar, Rujun Shen and Anshuman Daga in SINGAPORE, Jane Wardell in SYDNEY, Ben Blanchard in BEIJING, Tim Hepher in PARIS and Mark Hosenball, David Brunnstrom and Lesley Wroughton in WASHINGTON; Writing by Dean Yates; Editing by Michael Perry)


Monday, December 29, 2014

Search Expands for Missing AirAsia Uet, U.S. Sends Warship

The multinational search now is focused on the Java Sea, but authorities also now are searching coastal land -- Read more on ScientificAmerican.com

Food and Medication Insecurity Tied to Poor Diabetes Control

People lacking reliable sources of food and medicine are more likely to have poor control over their diabetes -- Read more on ScientificAmerican.com

What Does A Smart Brain Look Like?

We all know someone who is not as smart as we are—and someone who is smarter. At the same time, we all know people who are better or worse than we are in a particular area or task, say, remembering facts or performing rapid mental math calculations. These variations in abilities and talents presumably arise from differences among our brains, and many studies have linked certain very specific tasks with cerebral activity in localized areas. Answers about how the brain as a whole integrates activity among areas, however, have proved elusive. Just what does a “smart” brain look like?


Now, for the first time, intelligence researchers are beginning to put together a bigger picture. Imaging studies are uncovering clues to how neural structure and function give rise to individual differences in intelligence. The results so far are confirming a view many experts have had for decades: not all brains work in the same way. People with the same IQ may solve a problem with equal speed and accuracy, but using a different combination of brain areas. [For more on IQ and intelligence, see “,” by Keith E. Stanovich.]





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Scramble Underway to Find Missing AirAsia Plane

Investigators heed lessons learned from downed Malaysian aircraft earlier this year


December 29, 2014 | |

The hunt is on to find AirAsia Flight 8501, which left Surabaya, Indonesia, en route to Singapore on Sunday and lost contact with air traffic controllers somewhere over the Java Sea. Already, reports have come in of possible oil slicks on the ocean about 100 miles from the last point of contact, and possible wreckage 700 miles away, which seems like a stretch. Experts are expressing caution about even speculating on such reports, given the troubles finding evidence of Malaysia Airlines Flight MH 370, which disappeared on March 8 with 239 people on board (what happened is still unknown). AirAsia is based in Malaysia, but the missing aircraft, an Airbus A320, belonged to an affiliated Indonesian company, according to the .


In an age in which people worry about being under surveillance, it is hard to imagine how an aircraft can suddenly go down without a clear crash location or cause, but reconstructing such events, and even tracking them when they are happening, is difficult for many reasons. has published several articles on technology that tracks or threatens airliners. These articles provide good perspective on theories that experts from around the world will consider in the coming days about what might have happened in the AirAsia case, as well as other airliner mysteries. Links are below.


[explains the holes in the international air-traffic tracking system]


[ways to stymie radar, such as electronic jamming and flying planes close to the ground]


[questions over the best way to protect civilian aircraft from surface-launched missiles]



Head Games

Match wits with the Mensa puzzlers -- Read more on ScientificAmerican.com

Instant Egghead - Why Do Some People Live to 100?

July 27, 2012 |

Every organism on Earth has an expiration date. For humans, it's around 78 years, but some people make it to 100 or beyond. Scientific American editor Katherine Harmon explains how these outliers outlive the rest of us.


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Robotic Men and Robotic Vehicles Explore Ancient Shipwrecks

See Inside

Scientists are using exotic technologies to excavate underwater shipwrecks with the same precision as an archaeological dig


By

Two thousand years ago a storm drove a Roman ship against a sheer rock wall on the north side of the remote Greek island of Antikythera. The boat sank, along with tons of treasure: coins, gold jewelry, dozens of large marble and bronze statues, and an extraordinary, bronze clockwork device now counted as the first analog computer.


The wreck lay at the sea bottom, 165 feet down, untouched until 1900, when one day sponge divers came upon it. The divers were equipped with little more than a helmet and a long hose to the surface for air; they struggled just to reach the decayed vessel. One of them died, and two others were paralyzed.



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Virtual Reality Comes to the Web—Maybe for Real This Time

Backed by Google and Mozilla, VR-enabled browsers and gear could soon immerse Web users in 3-D worlds


December 29, 2014 | |

WEB VR FOR REAL: Gadgets that can take advantage of Web VR include the still-in-beta (via Facebook) and (pictured here).


Get ready to take the stage with Paul McCartney. If that’s not your thing, you can test-drive the latest SUV before it's available in showrooms or experience a movie as though you're in the scene. That's been (VR) for years, although stepping into an immersive virtual world has always required expensive stereoscopic head-mounted displays and other specialized equipment.A new, more accessible form of virtual reality delivered via the Web promises to let people experience digital worlds in 3-D using head-mounted displays connected to a variety of browser-enabled devices. Web VR is expected to offer the ability to move you from one immersive experience to another with a click of the mouse, touch of the screen or nod of the head. Web VR will let software developers port their virtual worlds to the Web, making them available for most VR hardware.Google and Mozilla are setting these wheels in motion within the next month or so when they deliver updated Chrome and Firefox browsers that support Web VR. earlier this year and the release of relatively inexpensive headsets from and Google provide further evidence that Web VR could be ready for wider use.VR for the massesvirtual reality modeling language, or VRML, aimed to allow the creation of virtual worlds—such as —linked together via the Web. But VRML could only be rendered using heavy-duty graphics workstations more likely found in a computer science lab or a data center than in one’s home. Although work on VRML , this first attempt was way ahead of the hardware.The availability of content will largely define Web VR’s success. Businesses have already begun buying into the concept of immersive advertising, thanks in large part to Facebook’s investment in Oculus. Beer brewery Dos Equis created a that places you at a fancy party with “.” To promote its new Volvo created , a virtual test drive and look at the car. Meanwhile the Sundance Film Festival's 2015 program, which showcases nontraditional and multimedia storytelling, will offer nine virtual reality works employing a variety of technologies. And Jaunt's virtual lets you walk around McCartney's piano, peering over his shoulder or looking into his eyes as he sings "Live and Let Die."All of these projects are app-based: Just like a smartphone app, you have to find them and download them individually to your computer or phone—and most of them will run on only one kind of headset. Available gadgets include the still-in-beta (targeted more at programmers than the average user) and . Google's DIY is an odd entry; the company offers directions to help you make a cardboard headset with lenses that you put over a smartphone to see VR content.Look for headsets to become more common as prices fall. "As we continue to see economies of scale, virtual reality gets smaller, faster and cheaper," says , lead experience designer on the Mozilla project.Immersive education and researchRyerson University, is developing , a digital tour of the human circulatory system using the Oculus Rift platform. Maldonado, the project’s leader, says he sees huge potential for Web distribution of this and other VR experiences.Online accessibility could also make Web VR appealing to psychology researchers, according to , director of the at the University of California, Santa Barbara. He regularly uses virtual environments to perform experiments because they eliminate the inescapable variations of interpersonal interactions. "With virtual reality you can create an experiment that runs the same for every subject," he says. But there's still the problem of recruiting a wide sample of subjects. "We don't often use representative samples—we know a lot about sophomores in college." If VR gear becomes cheap and widely accessible, experimenters could recruit more diverse sample groups using IP addresses, he adds.Virtual reality, actual softwareMozVR.com, a simple directory of virtual reality Web sites.Browser support is a work in progress. Brandon Jones, an engineer on Google's Chrome browser team, is working to add Web VR interfaces to Chrome, coordinating with Mozilla to make sure that VR content will run consistently in both browsers. "If only one browser supports this or different browsers support it in divergent ways, it won't be as compelling," he says. When contacted, Microsoft would not say whether it plans to enable Web VR in its Internet Explorer browser.New authoring tools in Chrome and Firefox should make it easier for Web developers to enable Web VR on their sites for those browsers. , an open-source project led by VRML pioneer , will let you use HTML-like tags and cascading style sheets, the basic tools of Web design, to create virtual worlds. And Unity, a popular 2-D and 3-D game-authoring tool, will support Web VR in an upcoming release. "We really believe that the Web could be the killer platform for virtual reality," Mozilla’s Carpenter says. "It is open, wild and creative."



Sunday, December 28, 2014

Banish Procrastination by Thinking Differently About Deadlines

What makes some tasks harder than others to tackle? It turns out the time allotted for the work matters less than how our mind perceives the deadline. When a deadline feels like it is part of the present—say, falling within the current calendar month—we are more likely to begin the task.


In one experiment, researchers asked 100 undergraduates when they would start a data-entry task that they had five days to complete. For some, the hypothetical assignment started April 24 or 25, whereas others got the job April 26 or 27. Although the groups had the same amount of time, the students with a deadline in early May were less willing to begin the task right away, according to the study, which appeared in the .


An experiment involving 295 farmers in India had a similar outcome. At a finance lecture, the farmers learned they could earn a monetary benefit if they opened a bank account and saved a certain amount within six months. One group's six-month deadline landed in December, another group's in January. Farmers whose deadline came before year's end were more likely to open the account immediately and more likely to meet the six-month savings goal.


The findings illustrate how the brain divides time into discrete categories, with boundaries at the end of a month or the start of a new year, for instance. To motivate yourself to start a task you are putting off, try thinking about time boundaries differently. For a deadline next month, you might call it three weeks instead—or design a new calendar for yourself that does not break up the months. The researchers also suggest dividing a task into incremental steps with their own deadlines, which will feel more immediate.


January Book Reviews Roundup

Books and recommendations from Scientific American -- Read more on ScientificAmerican.com

January Book Reviews Roundup

Books and recommendations from Scientific American -- Read more on ScientificAmerican.com

Pacemaker Powered by Heartbeats Has Watch Parts

Electronic pacemakers time the heartbeats of more than three million people in the U.S. For these patients, surgery is a regular occurrence. A pacemaker's batteries must be swapped out every five to eight years, and the electric leads that connect the device to the heart can wear out, too.


In an effort to eliminate the batteries and leads altogether, biomedical engineers at the University of Bern in Switzerland have built a heartbeat-powered pacemaker, assembled from self-winding clockwork technology that is more than two centuries old.


Automatic wristwatches, invented in 1777, contain a weighted rotor that turns when a wearer's wrist moves. The rotor winds up a spring, and when the fully coiled spring unwinds, it turns the watch's gears. In modern versions, the gears drive a tiny current-producing generator.


Like the jostling of a wrist, a beating heart can also wind a spring, the Swiss team found. The researchers stripped an automatic wristwatch of its time-indicating parts, enclosed the winding mechanism in a three-centimeter-wide case and sutured it to a live pig's heart. The prototype produced 50 microwatts of power; pacemakers need about 10.


The device currently has a “messy setup,” says Adrian Zurbuchen, who presented details about it at the European Society of Cardiology Congress late last summer. Wires connect the watch parts to a box containing electronics and a pacemaker. The goal is to have everything in one device. It will not be ready for prime time soon, predicts Spencer Rosero, who is director of the pacemaker clinic at the University of Rochester Medical Center and was not involved in the project. He says if tests are successful, medicine will most likely first see a pacemaker with both a battery and energy-harvesting components.


Saturday, December 27, 2014

Pacemaker Powered by Heartbeats Has Watch Parts

Electronic pacemakers time the heartbeats of more than three million people in the U.S. For these patients, surgery is a regular occurrence. A pacemaker's batteries must be swapped out every five to eight years, and the electric leads that connect the device to the heart can wear out, too.


In an effort to eliminate the batteries and leads altogether, biomedical engineers at the University of Bern in Switzerland have built a heartbeat-powered pacemaker, assembled from self-winding clockwork technology that is more than two centuries old.


Automatic wristwatches, invented in 1777, contain a weighted rotor that turns when a wearer's wrist moves. The rotor winds up a spring, and when the fully coiled spring unwinds, it turns the watch's gears. In modern versions, the gears drive a tiny current-producing generator.


Like the jostling of a wrist, a beating heart can also wind a spring, the Swiss team found. The researchers stripped an automatic wristwatch of its time-indicating parts, enclosed the winding mechanism in a three-centimeter-wide case and sutured it to a live pig's heart. The prototype produced 50 microwatts of power; pacemakers need about 10.


The device currently has a “messy setup,” says Adrian Zurbuchen, who presented details about it at the European Society of Cardiology Congress late last summer. Wires connect the watch parts to a box containing electronics and a pacemaker. The goal is to have everything in one device. It will not be ready for prime time soon, predicts Spencer Rosero, who is director of the pacemaker clinic at the University of Rochester Medical Center and was not involved in the project. He says if tests are successful, medicine will most likely first see a pacemaker with both a battery and energy-harvesting components.


A World of Tiny Movements [Video]

See Inside

The video "motion microscope" makes invisible changes visible in people and objects


Dec 16, 2014 | |

By amplifying color changes in videos, pixel by pixel, researchers have been able to make the imperceptible movements behind such changes obvious to the naked eye.


1. While the lefthand video shows an immobile face, the righthand video shows periodic red flushes, driven by a pulse.


2. Amplified still further, such color changes can highlight a baby's stomach moving as it breathes, a motion that is normally impossible to see.


3. The technique can also show that a construction crane, seemingly still, is actually shaking in the wind.


4. The motion microscope also shows how a pipe vibrates into different shapes when struck by a hammer, a technique that could help engineers detect structural defects.


Neil Degrasse Tyson's Christmas Tweets Caused A Brouhaha

It seems that a few harmless tweets by Astrophysicist Neil Degrasse Tyson are causing quite a stir on the internet.

Honest, I don't see this as being a big deal. I don't even find it mildly offensive and I wish those people who are criticizing him for it would explain what exactly it is that they don't like. After all, it appears that his words actually meant something for them to either follow him, or take the time to respond. Otherwise, why bother or give a hoot about what he has to say?


There are more offensive things being said and done against Christianity, especially at this time of the year. Picking a fight based on a bunch of FACTS (yes, look closely, he is simply stating FACTS) being presented in a rather cheeky way is a freaking waste of time! So get a GRIP, people!


Zz.



Friday, December 26, 2014

Online Survey: Do You Believe That Free Will Exists?

See Inside

Vote ‘yes’ or ‘no’ on this seminal question that has perplexed philosophers for millenia


Dec 16, 2014 | |free will

Is Nahmias right and the impression that many of us have is correct: We have the free will to choose one course of action over another. Or are you in the opposite camp?


More In This Article


Philosopher Eddy Nahmias from Georgia State University in support of the idea that free will exists. Our ability to choose left versus right, he thinks, prevails—even when, unbeknownst to all of us, our brains sometimes appear to be grinding away behind the scenes immediately before we actually take a step or utter the first word of a sentence.


Some other philosophers and neuroscientists disagree with Nahmias’s interpretation, however. They point to the same studies that suggest unconscious processes drive our every action—and then conclude free will is nothing more than an illusion.


Whether or not free will actually exists has all sorts of moral and legal consequences:


“My brain made me do it, judge.”


This is an age-old debate that dates back to the ancients. It will likely continue for millennia to come. The debaters need not be confined to the ranks of professional philosophers and neuroscientists.


So we’d like to hear what you think. Is Nahmias right and the impression that many of us have is correct: We have the free will to choose one course of action over another. Or are you in the opposite camp? Do you think our brains decide for us without our being conscious of the machinery by which they carry out subliminal decision-making processes?


Help us out and vote yes or no below. Also, if you wish, leave a comment about why you agree or disagree with the idea that our conscious selves still retain control over what we decide.


The survey will remain on our site until January 10, at which time we will post the results.



Keep Your 2015 Resolutions

Whether you want to conquer bad habits or build a healthier routine, you can learn how to pick and stick to any goal -- Read more on ScientificAmerican.com

Readers Respond to "The Power of Reflection"

THINKING ABOUT THINKINGThe Power of Reflection,” by Stephen M. Fleming]. In reflecting on it, considering that metacognition is probably formed in large part with the help of external feedback, it occurs to me that for the past several decades, vast swaths of Americans have most likely had their metacognition impaired by unconditional positive reinforcement (for instance, unearned positive feedback or grade inflation), lack of punishment and drug abuse.


I have noticed that in mainstream American society many people have undue levels of confidence, which perhaps can be explained by impaired metacognition. This phenomenon is important because in matters such as hiring and mating we depend in no small part on one another's metacognition. Overconfidence or underconfidence can have direct consequences in many contexts, such as the above, and indirect consequences in many others downstream, such as the economy, unemployment, social discord, health and evolution.


JORY MELTZER


Another very enjoyable issue. Fleming's article was very well done. In his discussion of dysfunction, I noticed that all of the research that was cited concerned problems of reduced metacognitive functioning. I wonder whether dysfunction might also result from overactive metacognitive functioning. Some research suggests that rumination is a central feature of depression, at least in a subpopulation of depressed individuals. Rumination tends to be self-focused, including thoughts about one's own depressive symptoms; as such, it could be characterized as overactive metacognition.


I have chronic depression. I tend to ruminate, and much of my rumination is metacognitive. In fact, I have often described it this way to therapists, complaining that I sometimes have two, or even three layers of metacognition running at the same time, making it extremely difficult to concentrate. I would be interested to find out whether any research has shown that people with depression exhibit hyperactivity of the regions involved in metacognition or hypoactivity in the regions that exert top-down executive control over metacognitive processes.


AARON KONOPASKY


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MIGRAINE LINK?An Unnerving Enigma.” Unfortunately, one fundamental view about the origin of the disorder was missing. Fibromyalgia is, like tension headaches and some other not so well defined pain disorders, only one symptom of central sensitization syndrome, also known as migraine syndrome. As mentioned in the article, patients do not have just pain but also fatigue, memory and mood problems, sleep disturbances, and a variety of symptoms of the dysregulation of the autonomic nervous system.


This symptomatology does not differ at all from that what we see in chronic migraine. The entire spectrum of symptoms does not always manifest at the same time, but over the years—if different epigenetic and stress factors generate more and more widespread neuronal dysfunction—we see one symptom after another rising and fading, typically in a rhythm of three to four months. As a neurologist, I've seen hundreds (if not thousands) of migraine patients also diagnosed with fibromyalgia. After recognizing more than 10 years ago that fibromyalgia is just one variation of the sensorineural dysfunctions seen in migraine syndrome, I have had many more treatment options to offer to my patients.


MATTI ILMAVIRTA


.


VIOLENCE AT HOMELove and Death,” inspired many letters to the editor. Some were complimentary: “Kudos to your magazine for publishing this story on domestic violence,” writes Kathryn Warren via e-mail. “All people need to be aware of the behavior signs of abusive persons so they can make better judgment calls before they invest in any relationship.”


Yet a few readers felt we focused unfairly on male violence toward women. “I agree most abuse comes from men, but women can also be abusive,” writes DeWayne Watts via e-mail. Research bears out this fact. Bressler responds, “That's true. Studies show that one out of seven men are battered in their relationship. It is important to note that number includes men in same-sex relationships. Men tend to experience verbal, emotional and financial abuse from their female partners; there are no specific studies that show at what rate women physically assault their partners.”


Many of you were concerned about the effect of domestic violence on children. “Men who abuse their wives don't abuse only their wives,” writes Michèle Gyselinck of Montreal. “Those who counsel women in abusive relationships might want to address the problem of how this abuse affects the kids, even if they aren't actually beaten themselves.” Bressler agrees and reports that many agencies do provide much needed counseling for children.


A couple of readers wrote in to suggest advice or further resources for victims. Paul Carney of Towson, Md., cautions that the article's recommendation to program the number for a shelter into a victim's phone could backfire: “Many abusers will check the victim's phone on a regular basis,” he writes. “The consequence of finding an unknown phone number, or that of a shelter, could be catastrophic.” Safety plans should indeed be tailored to each victim's circumstance, Bressler concurs. For a deeper discussion of abusive relationships and solutions, Citizens Advice Bureau counselor Michael Egan of St. Helens, England, suggests the highly regarded by Lundy Bancroft (Berkeley Books, 2003).


The big question on many of your minds is: How can we change our culture so that abuse happens less frequently? “As an educator and parent of a young child, I am wondering what we can do much earlier in life to foster the development of women who would reject a partner's complete control of her finances, behavior and physical appearance and, furthermore, would recognize it right away as abuse,” writes Liz Swan via e-mail. Bressler reports that many schools in the U.S. have programs for middle school and high school children in which they learn about healthy and nonhealthy relationship behaviors. “I would also suggest that any parent engage their children about what they believe is healthy and not healthy in a partnership,” Bressler says. “We must begin the conversation with young children, in an age-appropriate way, so that they understand they are equal in their intimate relationships.” —


Book Review: Cosmigraphics

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Books and recommendations from


Dec 16, 2014


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Cosmigraphics: Picturing Space through TimeAbrams, 2014 ($50)


Long before Hubble Space Telescope photographs wowed us with their beauty, other images of the cosmos awed us as well. This oversized art book samples humanity's attempts to depict the heavens throughout history. Some works are scientific; others are religious or purely artistic. Examples include modern supercomputer simulations of a sunspot, a 16th-century French painting of a solar eclipse and a bronze-and-gold image from Germany of the Pleiades star cluster dating to 2000–1600 b.c.—possibly the oldest known graphic depiction of celestial objects. Photographer and writer Benson gathers around 300 pictures in this collection, which illustrates both how much our knowledge of astronomy has progressed and how timeless the human fascination with celestial images is.


Thursday, December 25, 2014

28 Santa-Approved Dog Science Articles

Can’t believe so-and-so said that in front of everyone? Is it time for a break from members of your own species? The dogs are here to help.


2014 was a big year for canine science, although that’s not entirely true. Every year, particularly since the , has been a ‘big year’ for canine science — a booming interdisciplinary field exploring who dogs are, where they came from, and their cognitive and emotional lives.


Here are 28 of my favorite dog science pieces of 2014. A few themes stand out, and I hope they carry into 2015:








Some pieces are here on Dog Spies, while others will take you elsewhere on the world wide web. When you arrive, take a tour of these dog science friendly sites. Dogs will thank you (and your family can wait).


I. Interspecies Friendships


1. , 2. Observing behavior is not a serious matter, but it could be incredibly important.


3. A dog is not a child, but maternal attachments might still be at play.


4. , 5. In 2014, animal lovers and practitioners lost a vibrant teacher, and companion animals lost a tireless advocate. We are thankful that Sophia Yin’s legacy continues. Get to know Sophia Yin’s training and handling resources ( and ).


II. The Big W: Difficult to See, Even When It’s Right There


6. Serious topic made, dare I say, enjoyable. Obesity is a welfare issue.


7. Guide dogs are awesome. They are also working. There’s a good chance your dog doesn’t know that.


8. No, it’s not zombies, although that would be unexpected. A study found that fear of unfamiliar people predicted decreased dog lifespan. Complex topic with resources for decreasing social and asocial fears.


9. Find out why.


10. Not all “scaredy” dogs have been mistreated. Why it matters that something else could be going on.


11. Dog professionals are better than dog owners at identifying fear in dogs. It doesn’t have to be that way.


12. , 13. Problems of and solutions to dog breeds.


III. Here’s Looking at Who You Are


14. , 15. What do dogs make of other dogs’ urine? The quest continues!


16. , 17. How dogs do this remains an outstanding question.


18. , ), and Jamie Wolf (


IV. Put That Cold Wet One to Work


19. The answer in Cat Warren’s book, ‘What the Dog Knows: The Science and Wonder of Working Dogs’ (, ).


20. Another of life’s great truths to ponder as we move into 2015.


V. 9 to 5!21.


22.


VI. I’m a Dog! My Mind is an Open Box!


23. , 24. Experts discuss learning and training questions.


25. , VII. Are Looks Deceiving?


26. THIS is what a product review should look like. is a space to watch for behavior observation, welfare and training!


27. What does the research say about aggressive behavior and ‘dangerous’ dogs?


28. The national association of veterinary behaviorists came out in opposition of breed-specific legislation. Find out why.


VIII. Bonus Edition!“Research into cat welfare is rare, so it’s a shame when it’s misreported.” I agree entirely. Although not as rare, this statement is for dog science.


A must read (and must see).


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Photo: Dressed for the season via Flickr Creative Commons.



NASA’s Asteroid Retrieval Mission Faces Criticism

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The agency’s proposed human trip to a space rock has a bumpy road ahead


Dec 16, 2014 | |

The Obama administration wants to send humans to Mars in the 2030s. Of course, such a mission requires a lot of advance engineering, and as a first step, nasa plans to send astronauts to a small asteroid that would be brought into a stable orbit around the moon. To achieve that mechanical feat, a solar-powered robotic probe is being designed to capture a space rock and slowly push it into place. A target asteroid has yet to be announced, and the robotic space tug has yet to be built, but the parties involved hope to have the rock relocated to the moon's vicinity as soon as 2021. nasa calls this concept the Asteroid Redirect Mission (ARM) and is marshaling resources across the entire agency to support it.


Michele Gates, the agency's program director for ARM, says that its advanced propulsion technology and crew activities would give nasa the capability and experience needed to someday reach Mars. The trip would demonstrate spacecraft rendezvous procedures and establish protocols for sample collection and extravehicular movements. And it would do all of this while keeping astronauts relatively safe, staying sufficiently close to home so that if something went wrong, the crew could potentially make an emergency return to Earth.


ARM's critics are loud and legion, however. In June the prestigious National Research Council issued a report stating that the mission could divert U.S. resources and attention from more worthy space exploration, highlighting parts of ARM as dead ends on the path to Mars. The harshest criticisms have come from asteroid scientists. Mark Sykes, director of the Planetary Science Institute in Tucson, Ariz., ridiculed ARM last September while testifying to a congressional committee, saying that the agency's tentative cost estimate of less than $1.25 billion for the concept's robotic component strained credulity.


“It doesn't advance anything,” Sykes says, “and everything that could benefit from it could be benefited far more by other, cheaper, more efficient means.”


The mission's detractors miss the point that it represents the nation's best opportunity in the foreseeable future to maintain its momentum in human spaceflight, says Louis Friedman, a space policy expert who helped to conceive ARM.


To this point, planetary scientist Richard Binzel of the Massachusetts Institute of Technology argues that NASA needs to look for more asteroids before it leaps into ARM. A robust asteroid survey, he says, would discover suitable targets for a crewed mission that would not require an expensive orbital relocation. “By the time we would tow a tiny rock into lunar orbit, we could be discovering more attractive, larger objects passing through the Earth-moon system that are easy to reach,” Binzel notes.


NASA plans to conduct a formal review of the ARM concept in February, and the Obama administration's next budget proposal is expected to request more funding for ARM. But the redirect's fate may have already been sealed by 2014's midterm elections, in which Republicans, who are largely opposed to the mission, took full control of Congress. With this latest blow to nasa's post–Space Shuttle plans for human spaceflight, the agency's astronauts may end up boldly going nowhere for many years to come—regardless of the approach.